The MONICA Brianza Study
MONICA Brianza Study:
The MONICA-Brianza Cohort Study is a prospective observational study of three cohorts of 25-64 years old residents in Brianza, a highly-industrialized area located between Milan and the Swiss border, Northern Italy. Gender- and 10-year age stratified samples were randomly drawn in 1986, 1990 and 1993, and cardiovascular risk factors were investigated at baseline following the procedures of the WHO MONICA Project (21). The overall participation rate was 69%. For all subjects whole blood and serum samples were stored in a biobank. The protocol was approved by the Monza Hospital Ethical Committee. Baseline examinations were carried out in 1986-87 for cohort 1 of N=1,659 response rate was 69%, Cohort 2 was collected in 1989-90 (N=1599), response rate was 67% and cohort 3 in 1993-1994 (N=1674), response rate was 69%. Study participants were enrolled and followed up for first coronary or stroke events, fatal and non-fatal (22), up to the end of 2008, for a median of 15 years.