The Cooperative Health Research in the Region of Augsburg (KORA)
Kooperative Gesundheitsforschung in der Region Augsburg (KORA):
The WHO Multinational Monitoring of Trends and Determinants in Cardiovascular Diseases (MONICA) / Cooperative Health Research in the Region of Augsburg (KORA) cohorts were randomly selected from representative sample surveys from the city of Augsburg and the less urban Landkreis Augsburg and Landkreis Aichach-Friedberg regions in Bavaria, Southern Germany. List of municipalities and population registers were used as sampling frames for the first and the second stage of two-stage sampling, respectively. The second stage of sampling was stratified by sex and 10-year age group. The Survey 3 (S3) baseline examination (1994-1995) was carried out as part of the WHO MONICA project and consists of 4,480 men and women aged 25-74 with a response rate of 74% (12). The Survey 4 baseline examination (S4) was carried out in 1999-2001 consisting of 3,019 men and women aged 25-74 who were re-examined with repeated measurements collected, in 2006-2008 (F4) with a response rate of 72% (13). S4 and F4 studies and morbidity and mortality follow-ups were conducted in the frame of KORA. Coronary events were identified through the MONICA/KORA Augsburg coronary event registry. Coronary deaths were validated by autopsy reports, death certificates, chart review from the last treating physician. Cases with self-reported incident diabetes were validated by the treating physician and medical records documenting use of antidiabetic medication. Self-reported cases of incident stroke were validated by medical records. Mortality follow-up until 2009 was conducted through national death registers.