The HAPIEE study

Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE):

The HAPIEE study comprises four prospective urban population based cohorts from Eastern Europe, including Novosibirsk (Russia), Krakow (Poland), Kaunas (Lithuania) and 7 cities of the Czech Republic (11). Each cohort recruited a random sample of men and women aged 45-69 years at baseline in 2002-05 (2006-08 in Lithuania), stratified by sex and 5-year age group. Participants were selected from population registers (electoral roll list in Russia). Participants completed extensive questionnaire, underwent examination in clinic and provided a blood sample. The sample size (response rates) were 9,360 (61%) in Russia; 10,728 (61%) in Poland; 7,161 (61%) in Lithuania; and 8,857 (55%) in the Czech Republic. Deaths in the cohorts were identified by linkages with national or regional death registers. Non-fatal cardiovascular events were identified via linkage with hospitalisation registers, MONICA registers and by repeated postal follow-up questionnaires validated against GP and hospital records. Follow-up is completed to 2011 for Czech Republic and Lithuania, to 2010 for Russia and to 2009 for Poland.


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