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The Publications

2018

Zeller T, Schnabel RB, Appelbaum S, Ojeda F, Berisha F, Schulte-Steinberg B, Brueckmann BE, Kuulasmaa K, Jousilahti P, Blankenberg S, Palossari T, Salomaa V, Karakas M. Low Testosterone Levels are Predictive for Incident Atrial Fibrillation and Ischemic Stroke in Men, but Protective in Women - Results from the FINRISK Study. Eur J Prev Cardiol accepted May 2018. doi: 10.1177/2047487318778346 [Epub ahead of print]

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Patterson CC, Blankenberg S, Ben-Shlomo Y, Heslop L, Bayer A, Lowe G, Zeller T, Gallacher J, Young I, Yarnell JWG. Troponin and BNP are markers for subsequent non-ischaemic congestive heart failure: the Caerphilly Prospective Study (CaPS). Open Heart 2018; 5(1):e000692

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Simes J, Robledo KP, White HD, Espinoza D, Stewart RA, Sullivan DR, Zeller T, Hague W, Nestel PJ, Glasziou PP, Keech AC, Elliott J, Blankenberg S, Tonkin AM; LIPID study investigators. D-dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events and Cancer in Stable Coronary Heart Disease Patients: The LIPID Study. Circulation 2018. doi: 10.1161/CIRCULATIONAHA.117.029901 [Epub ahead of print].

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Schofer N, Ludwig S, Rübsamen N, Schnabel R, Lackner KJ, Ruprecht HJ, Bickel C, Landmesser U, Blankenberg S, Zeller T. Prognostic impact of Interleukin-1 receptor antagonist in patients with documented coronary artery disease. Int J Cardiol 2018; 15; 257:24-29.

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Magnussen C, Ojeda FM, Wild PS, Sörensen N, Rostock T, Hoffmann BA, Prochaska J, Lackner KJ, Beutel ME, Blettner M, Pfeiffer N, Rzayeva N, Sinning CR, Blankenberg S, Münzel T, Zeller T, Schnabel RB. Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study). Am J Cardiol 2018; 122(1):76-82.

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Sörensen NA, Neumann JT, Ojeda F, Schäfer S, Magnussen C, Keller T, Lackner KJ, Zeller T, Karakas M, Münzel T, Blankenberg S, Westermann D, Schnabel RB. Relations of Sex to Diagnosis and Outcomes in Acute Coronary Syndrome. J Am Heart Assoc 2018; 7(6).

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2017

Waldeyer C, Makarova N, Zeller T, Schnabel RB, Brunner FJ, Jørgensen T, Linneberg A, Niiranen T, Salomaa V, Jousilahti P, Yarnell J, Ferrario MM, Veronesi G, Brambilla P, Signorini SG, Iacoviello L, Costanzo S, Giampaoli S, Palmieri L, Meisinger C, Thorand B, Kee F, Koenig W, Ojeda F, Kontto J, Landmesser U, Kuulasmaa K, Blankenberg S. Lipoprotein(a) and the risk of cardiovascular disease in the European population: results from the BiomarCaRE consortium. Eur Heart J 2017; 38(32):2490-2498.

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Magnussen C, Niiranen TJ, Ojeda FM, Gianfagna F, Blankenberg S, Njølstad I, Vartiainen E, Sans S, Pasterkamp G, Hughes M, Costanzo S, Donati MB, Jousilahti P, Linneberg A, Palosaari T, de Gaetano G, Bobak M, den Ruijter HM, Mathiesen E, Jørgensen T, Söderberg S, Kuulasmaa K, Zeller T, Iacoviello L, Salomaa V, Schnabel RB; BiomarCaRE Consortium. Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors and Mortality in Community Cohorts. Circulation 2017; 136(17):1588-1597.

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Hughes MF, Ojeda F, Saarela O, Jørgensen T, Zeller T, Palosaari T, O'Doherty MG, Borglykke A, Kuulasmaa K, Blankenberg S, Kee F. Association of Repeatedly Measured High-Sensitivity-Assayed Troponin I with Cardiovascular Disease Events in a General Population from the MORGAM/BiomarCaRE Study. Clin Chem 2017; 63(1):334-342.

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Zeller T, Schurmann C, Schramm K, Müller C, Kwon S, Wild PS, Teumer A, Herrington D, Schillert A, Iacoviello L, Kratzer A, Jagodzinski A, Karakas M, Ding J, Neumann JT, Kuulasmaa K, Gieger C, Kacprowski T Schnabel RB, Roden M, Wahl S, Rotter Jl, Ojeda F, Carstensen-Kirberg M, Tregouet DA, Dörr M, Meitinger T Lackner KJ, Wolf P, Felix SB, Landmesser U Costanzo S, Ziegler A, Liu Y, Völker U, Palmas W, Prokisch H, Guo X, Herder C, Blankenberg S, Homuth G. Transcriptome-wide analysis identifies novel associations with blood pressure. Hypertension 2017; 70 (4):743-750.

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Sinning C, Ojeda F, Wild PS, Schnabel RB, Schwarzl M, Ohdah S, Lackner KJ, Pfeiffer N, Michal M, Blettner M, Munzel T, Kempf T, Wollert KC, Kuulasmaa K, Blankenberg S, Salomaa V, Westermann D, Zeller T. Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients. Clin Res Cardiol 2017; 106(6):401-410.

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Karakas M, Schulte C, Appelbaum S, Ojeda F, Lackner KJ, Münzel T, Schnabel RB, Blankenberg S, Zeller T. Circulating microRNAs strongly predictcardiovascular death in patients with coronary artery disease-results from the large AtheroGene study. Eur Heart J 2017; 38(7):516-523.

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2016

Kettunen J, Demirkan A, Würtz P, Draisma HH, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikäinen LP, Pirinen M, Pool R, Sarin AP, Soininen P, Tukiainen T, Wang Q, Tiainen M, Tynkkynen T, Amin N, Zeller T, Beekman M, Deelen J, van Dijk KW, Esko T, Hottenga JJ, van Leeuwen EM, Lehtimäki T, Mihailov E, Rose RJ, de Craen AJ, Gieger C, Kähönen M, Perola M, Blankenberg S, Savolainen MJ, Verhoeven A, Viikari J, Willemsen G, Boomsma DI, van Duijn CM, Eriksson J, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, Slagboom PE, Waldenberger M, Ripatti S, Ala-Korpela M. Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun 2016; 7:11122.

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Hughes MF, Patterson CC, Appleton KM, Blankenberg S, Woodside JV, Donnelly M, Linden G, Zeller T, Esquirol Y, Kee F. The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers. Psychosom Med 2016; 78(4):401-11.

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Atzler D, Baum C, Ojeda F, Keller T, Cordts K, Schnabel RB, Choe CU, Lackner KJ, Münzel T, Böger RH, Blankenberg S, Schwedhelm E, Zeller T. Low Homoarginine Levels in the Prognosis of Patients with Acute Chest Pain. J Am Heart Assoc 2016; 5(4):e002565.

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Blankenberg S, Salomaa V, Makarova N, Ojeda F, Wild P, Lackner KJ, Jørgensen T, Thorand B, Peters A, Nauck M, Petersmann A, Vartiainen E, Veronesi G, Brambilla P, Costanzo S, Iacoviello L, Linden G, Yarnell J, Patterson CC, Everett BM, Ridker PM, Kontto J, Schnabel RB, Koenig W, Kee F, Zeller T, Kuulasmaa K; BiomarCaRE Investigators. Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium. Eur Heart J 2016; 37(30):2428-37.

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Dankowski T, Ziegler A: Calibrating random forests for probability estimation. Stat Med 2016; 35(22):3949-60.

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Ordóñez-Mena JM, Schöttker B, Mons U, Jenab M, Freisling H, Bueno-de-Mesquita B, O'Doherty MG, Scott A, Kee F, Stricker BH, Hofman A, de Keyser CE, Ruiter R, Söderberg S, Jousilahti P, Kuulasmaa K, Freedman ND, Wilsgaard T, de Groot LC, Kampman E, Håkansson N, Orsini N, Wolk A, Nilsson LM, Tjønneland A, Pająk A, Malyutina S, Kubínová R, Tamosiunas A, Bobak M, Katsoulis M, Orfanos P, Boffetta P, Trichopoulou A, Brenner H; Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES). Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium. BMC Med 2016; 14(1), 62.

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Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer CM, El-Mokhtari NE, Franke A, Gottesman O, Heilmann S, Hengstenberg C, Hoffmann P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Müller-Nurasyid M, Nikpay M, Olivieri O, Perreault LP, AlQarawi A, Robertson NR, Akinsanya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Strauch K, Varga TV, Waldenberger M, Zeng L, Kraja AT, Liu C, Ehret GB, Newton-Cheh C, Chasman DI, Chowdhury R, Ferrario M, Ford I, Jukema J, Kee F, Kuulasmaa K, Nordestgaard BG, Perola M, Saleheen D, Sattar N, Surendran P, Tregouet D, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh G, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader DJ, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Kathiresan S, Deloukas P, Samani NJ, Schunkert H. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med 2016, 374(12), 1134-44.

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Veronesi G, Ferrario MM, Kuulasmaa K, Bobak M, Chambless LE, Salomaa V, Soderberg S, Pajak A, Jørgensen T, Amouyel P, Arveiler D, Drygas W, Ferrieres J, Giampaoli S, Kee F, Iacoviello L, Malyutina S, Peters A, Tamosiunas A, Tunstall-Pedoe H, Cesana G. Educational class inequalities in the incidence of coronary heart disease in Europe. Heart 2016; 102(12):958-65.

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Wright MN, Ziegler A. ranger: A Fast Implementation of Random Forests for High Dimensional Data in C++ and R. estimation. J Stat Softw 2016; vol. 77(i01).

Wright MN, Ziegler A, König IR. Do little interactions get lost in dark random forests? BMC Bioinformatics 2016; 17:145.

2015

Jagodzinski A, Havulinna AS, Appelbaum S, Zeller T, Jousilahti P, Skytte-Johanssen S, Hughes MF, Blankenberg S, Salomaa V. Predictive value of galectin-3 for incident cardiovascular disease and heart failure in the population-based FINRISK 1997 cohort. Int J Cardiol 2015; 192:33-9.

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Tonkin AM, Blankenberg S, Kirby A, Zeller T, Colquhoun DM, Funke-Kaiser A, Hague W, Hunt D, Keech AC, Nestel P, Stewart R, Sullivan DR, Thompson PL, West M, White HD, Simes J; LIPID study investigators. Biomarkers in stable coronary heart disease, their modulation and cardiovascular risk: The LIPID biomarker study. Int J Cardiol 2015; 201:499-507.

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Schulte C, Molz S, Appelbaum S, Karakas M, Ojeda F, Lau DM, Hartmann T, Lackner KJ, Westermann D, Schnabel RB, Blankenberg S, Zeller T. miRNA-197 and miRNA-223 predict cardiovascular death in a cohort of patients with symptomatic coronary artery disease. PLoS One 2015; 10(12):e0145930.

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Everett BM, Zeller T, Glynn RJ, Ridker PM, Blankenberg S (): High-sensitivity cardiac troponin I and B-type natriuretic Peptide as predictors of vascular events in primary prevention: impact of statin therapy. Circulation 2015; 131(21), 1851-60.

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Jagodzinski A, Havulinna AS, Appelbaum S, Zeller T, Jousilahti P, Skytte-Johanssen S, Hughes MF, Blankenberg S, Salomaa V: Predictive value of galectin-3 for incident cardiovascular disease and heart failure in the population-based FINRISK 1997 cohort. Int J Cardiol 2015; 192:33-9.

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Leitsalu L, Haller T, Esko T, Tammesoo ML, Alavere H, Snieder H, Perola M, Ng PC, Mägi R, Milani L, Fischer K, Metspalu A: Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu. Int J Epidemiol 2015; 44(4), 1137-47.

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Milani L1, Leitsalu L, Metspalu A: An epidemiological perspective of personalized medicine: the Estonian experience. J Intern Med 2015; 277(2), 188-200.

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Mons U, Müezzinler A, Gellert C, Schöttker B, Abnet CC, Bobak M, de Groot L, Freedman ND, Jansen E, Kee F, Kromhout D, Kuulasmaa K, Laatikainen T, O'Doherty MG, Bueno-de-Mesquita B, Orfanos P, Peters A, van der Schouw YT, Wilsgaard T, Wolk A, Trichopoulou A, Boffetta P, Brenner H; CHANCES Consortium). Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium. BMJ 2015; 350:h1551.

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Müezzinler A, Mons U, Gellert C, Schöttker B, Jansen E, Kee F, O'Doherty MG, Kuulasmaa K, Freedman ND, Abnet CC, Wolk A, Håkansson N, Orsini N, Wilsgaard T, Bueno-de-Mesquita B, van der Schouw YT, Peeters PH, de Groot LC, Peters A, Orfanos P, Linneberg A, Pisinger C, Tamosiunas A, Baceviciene M, Luksiene D, Bernotiene G, Jousilahti P, Petterson-Kymmer U, Jansson JH, Söderberg S, Eriksson S, Jankovic N, Sánchez MJ, Veronesi G, Sans S, Drygas W, Trichopoulou A, Boffetta P, Brenner H. Smoking and All-cause Mortality in Older Adults: Results From the CHANCES Consortium. Am J Prev Med 2015; 49(5), e53-63.

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Tunstall-Pedoe H, Woodward M, Hughes M, Anderson A, Kennedy G, Belch J, Kuulasmaa K; MORGAM Investigators. Prime mover or fellow traveller: 25-hydroxy vitamin D's seasonal variation, cardiovascular disease and death in the Scottish Heart Health Extended Cohort (SHHEC). Int J Epidemiol 2015; 44(5), 1602-12.

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2014

Ferrario MM, Veronesi G, Chambless LE, Tunstall-Pedoe H, Kuulasmaa K, Salomaa V, Borglykke A, Hart N, Söderberg S, Cesana G; for the MORGAM Project The contribution of educational class in improving accuracy of cardiovascular risk prediction across European regions: The MORGAM Project Cohort Component. Heart 2014;100(15):1179-87.

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Funke-Kaiser A, Havulinna, AS, Zeller T, Appelbaum S, Jousilahti P, Vartiainen E, Blankenberg S, Sydow K, Salomaa V: Predictive value of midregional pro-adrenomedullin compared to natriuretic peptides for incident cardiovascular disease and heart failure in the population-based FINRISK 1997 cohort. Annals of Medicine 2014; 46(3), 155-62.

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Hughes MF, Appelbaum S, Havulinna AS, Jagodzinski A, Zeller T, Kee F, Blankenberg S, Salomaa V: ST2 may not be a useful predictor for incident cardiovascular events, heart failure and mortality in the population-based FINRISK 1997 cohort and the BiomarCaRE project. Heart 2014; 100(21), 1715-1721.

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Neumann JT, Havulinna AS, Zeller T, Appelbaum S, Kunnas T, Nikkari S, Jousilahti P, Blankenberg S, Sydow K, Salomaa V: Comparison of Three Troponins as Predictors of Future Cardiovascular Events – Prospective Results from the FINRISK and BiomaCaRE Studies. PLoS ONE 2014; 9(3):e90063.

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Siemelink M, Zeller T. Biomarkers of Coronary Artery Disease – The promise of the transcriptome. Current Cardiology Reports 2014; 16(8):513.

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Zeller T, Hughes M, Tuovinen T, Schillert A, Conrads-Frank A, Ruijter HD, Schnabel RB, Kee F, Salomaa V, Siebert U, Thorand B, Ziegler A, Breek H, Pasterkamp G, Kuulasmaa K, Koenig W, Blankenberg S: BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries. Eur J Epidemiol 2014; 29(10):777-90.

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Zeller T, Keller T, Ojeda F, Reichlin T, Twerenbold R, Tzikas S, Wild PS, Reiter M, Czyz E, Lackner KJ, Munzel T, Mueller C, Blankenberg S.: Assessment of microRNAs in patients with unstable angina pectoris. Eur Heart J 2014; 35(31):2106-14.

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Zeller T, Ojeda F, Brunner FJ, Peitsmeyer P, Münzel T, Binder H, Pfeiffer N, Michal M, Wild PS, Blankenberg S, Lackner KJ: High-sensitivity cardiac troponin I in the general population - defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study. Clin Chem Lab Med 2014; 53(5), 699-706.

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Zeller T, Tunstall-Pedoe H, Saarela O, Ojeda F, Schnabel RB, Tuovinen T, Woodward M, Struthers A, Hughes M, Kee F, Salomaa V, Kuulasmaa K, Blankenberg S; MORGAM Investigators (): High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort. Eur Heart J 2014; 35(5): 271-81.

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flag eu  The BiomarCaRE project was co-funded by the European Community´s Seventh Framework Programme (FP7/2007-2013) under grant agreement N° HEALTH-F2-2011-278913.