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Project Description

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Europa-Studien Apr14 webFigure 1: Population cohorts (blue), disease cohorts (red) and clinical trials (green) participating in BiomarCaREBiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) is an EU FP7-funded collaborative research project that integrates clinical, epidemiological and biomarker research, as well as commercial enterprises throughout Europe, North America and Australia. The BiomarCaRE project aims to determine the additional value of multiple (new) biomarkers to improve risk estimation of cardio vascular diseases (CVD) related events in Europe. Ultimately, our BiomarCaRE consortium will develop a "European biomarker panel" for CVD prediction including the classical risk factors and established and novel biomarkers.

The UKE Hamburg is coordinating the collaborative BiomarCaRE consortium which integrates the efforts of 25 academic institutions and five small/medium-sized, research intensive enterprises (SMEs) with a focus on cardiovascular biomarker research across Europe. BiomarCaRE comprises 21 well-established prospective European population-based cohort studies, four cohorts of diseased subjects (disease cohorts, secondary prevention) and five clinical trials, totalling over 300,000 participants with follow-up (Figure 1). The central BiomarCaRE laboratory is directly located at the University Heart Center Hamburg where sample logistics and biomarker measurements but also data analyses has been performed.
Novel, -omics based biomarkers (origination from proteomics, transcriptomics, metabolomics and miRNomics) are disclosed by the academic and SME partners and compared to key established biomarkers such as high-sensitivity assayed troponin I, natriuretic peptides, high-sensitivity C-reactive protein, lipids, and further markers of cardiomyocyte micronecrosis, inflammation, und renal function. The SMEs introduce the technology and guide the development of the innovative assays needed for the measurement of these novel biomarkers.

The BiomarCaRE Project is designed as a multi-modular study including:
  1. biomarker selection based on omics discovery studies as well as literature, and
  2. assay development (Module 1),
  3. data harmonization of large-scale studies and
  4. biomarker determination, analyses and validation (Module 2), and
  5. biomarker assessment in clinical trials and 6) economic evaluation (Module 3) (Figure 2).

The BiomarCaRE project is unique in terms of its dimension, targeting of novel biomarkers based on -omics technology, and the evaluation of the impact of a multiple biomarker score in large prospective population cohorts across different European regions. BiomarCaRE integrates modern, mainly SME driven molecular technologies with epidemiological approaches supplemented by economical assessment. This large individual-based database provides a unique opportunity to investigate the performance of established and novel biomarkers for cardiovascular risk assessment across Europe.

Flow webFigure 2: BiomarCaRE modules.