Print

Workpackage 7: Data harmonization and statistical analysis

on . Posted in Project

Objectives
  • To assess the impact of the biomarkers, and develop and validate risk estimation models based on classic cardiovascular risk factors and biomarkers of the assays established in Module 1, using large prospective European population and diseased cohorts.
  • To assess the impact of lifestyle on the level of the biomarkers and the association between the biomarkers and diagnostic imaging phenotypes

Description of Work

The impact of the biomarkers is assessed in a large number of population cohorts from 14 European countries and in five cohorts of persons who already have cardiovascular disease at baseline. All cohorts have prospective follow-up for cardiovascular disease, and many are followed up also for diabetes. Relevant data from the population cohorts are harmonized to the MORGAM database in the BiomarCare Data Centre in Helsinki. Data from the diseased cohorts are harmonized in the BiomarCaRE Data Centre in Lübeck. These Data Centres assess the quality and cohort-specific characteristics of the data, analyze the data and also share the data with other BiomarCaRE Partners for data analysis.

The data analysis involves the assessment of the impact of the biomarkers on the cardiovascular end-points in population cohorts of about 90,000 men and women, 30,000 repeat measurements and 8,850 subjects of the diseased cohorts. Some of the biomarkers are assessed in a case-cohort setting in 20,000 subjects instead of all 90,000. Risk models based on classic cardiovascular risk factors and biomarkers are derived and validated internally. The most promising biomarkers will be validated in separate population cohorts of about 130,000 subjects.

A BiomarCaRE Panel, the set of the most promising biomarkers, will be defined, and applied in clinical trials in WP 8.

The impact of lifestyle on the level of the biomarkers and the association between the biomarkers and diagnostic imaging phenotypes are analyzed locally in the BiomarCaRE Centres whose cohorts have such data available.


Partners involved

THL Helsinki (WP coordinator), UHSH Lübeck, UKE Hamburg, all cohort providers